The effect of positive end-expiratory pressure on intracranial pressure and cerebral hemodynamics

Gil Ben-Horin
Published: Nov 16, 2016

A study performed at Beth Israel Deaconess Medical Center evaluated the effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in a large population of patients with acute brain injury and varying categories of acute lung injury, defined by PaO2/FiO2. The authors hypothesised that PEEP could be applied safely to patients with severe brain injury without causing intracranial hypertension or dangerous reductions in CPP. The authors conclude that “the application of PEEP for patients with varying degrees of acute lung injury and concomitant severe, acute brain injury does not appear to have a clinically significant effect on ICP or CPP. However, our findings should be applied with caution as further prospective studies are needed to assess the safety and clinical outcomes of applying a lung protective ventilation strategy to patients with both lung and brain injuries.” In this study, the largest analysis of the relationship between PEEP and ICP, MetaVision was used to identify eligible patients and collect ventilation, physiologic, laboratory, medication, and demographic data.

Back to lobby

The effect of positive end-expiratory pressure on intracranial pressure and cerebral hemodynamics

Clinically relevant potential drug-drug interactions in intensive care patients: A large retrospective observational multicenter study

Bedside dynamic calculation of mechanical power: A validation study. Journal of Critical Care

Direct feeding at the breast is associated with breast milk feeding duration among preterm infants