Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy

Gil Ben-Horin
Published: Oct 16, 2016

A study performed at Johns Hopkins Hospital evaluated the effect of red blood cell average storage duration on perioperative infectious complications and overall morbidity in patients undergoing radical cystectomy (RC), a high- risk patient population, using clinically relevant definitions of older blood. We hypothesise perioperative blood transfusion with blood stored for longer average duration are associated with higher rates of perioperative infection and morbidity in patients undergoing RC. Patients who underwent RC for bladder cancer at Johns Hopkins Hospital between January 2010 and December 2014 were analysed using data from MetaVision, among other systems. The authors found that although blood is stored up to 42 days, storage of 28 days or more may expose RC patients to increased perioperative infections and overall morbidity compared with storage of less than 28 days. They suggest that prospective cohort studies are performed in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration.

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Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy

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