Impact of chloride and strong ion difference on ICU and hospital mortality in a mixed intensive care population

Gil Ben-Horin
Published: Sep 16, 2016

A large-scale retrospective cohort study at Antwerp University Hospital examined the association between abnormal chloremia and ICU and hospital mortality. The authors assessed the link with mortality both on the ICU and in the hospital, retrieving data such as demographic information, SAPS-3 and reason for admission from MetaVision. The authors found that after careful controlling for confounders, hyperchloremia was significantly associated with increased 30-day ICU and hospital mortality, but did not find that a low strong ion difference to be linked with negative outcome. They conclude that there is no simplistic extrapolation of their and other findings on hyperchloremia to the ongoing discussion on the detrimental effects of chloride-rich solutions.

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Impact of chloride and strong ion difference on ICU and hospital mortality in a mixed intensive care population

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