A systematic review and a meta-analysis of evidence of the impact of commercial computerized provider order entry (CPOE) and clinical decision support systems (CDSSs) on medication errors, LOS, and mortality in ICUs was performed. The authors found that the transition from paper-based ordering to commercial CPOE systems in ICUs was found to be associated with an 85% reduction in medication prescribing error rates. Studies based on MetaVision were included in this review. The authors conclude that, “While limited, the current evidence base suggests that the implementation of commercial CPOE systems can significantly decrease the frequency of medication prescribing error rates, as well as reducing the risk of mortality in ICUs. Future studies that aim to examine medication errors and patient outcomes should ensure they have sufficient sample sizes that are powered to identify the true effect of CPOE implementation. There is also a critical need to understand the nature of errors arising post-CPOE and how the addition of advanced CDSSs can be used to provide even greater benefit to delivering safe and effective patient care.”

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